Intravas 40mg Injection

✔️ Uses of Intravas 40mg Injection

• Treats and prevents blood clots in the body

✔️ How does Intravas 40mg Injection work?

 Intravas 40mg Injection works by interfering with the normal clotting process and decreasing the clot-forming ability of the blood.

✔️ Side Effects of Intravas 40mg Injection

• Increases in liver enzymes
• Bruise more easily than usual
• Pink patches on your skin
• Skin rash (hives, urticaria)
• Itchy red skin
• Bruising or pain at the injection site
• Decreased red blood cell count
• High platelet counts in the blood

✔️ Quick Suggestions:

• You have been prescribed  Intravas 40mg Injection(0.4ml Each) for the treatment and prevention of blood clots.
• Intravas 40mg Injection (0.4ml Each) increases your risk of bleeding. Be careful while shaving, using sharp objects, or cutting fingernails or toenails.
• Inform your doctor if you are also taking other medicines that increase the bleeding risk like aspirin and NSAIDs.
• Inform your doctor if there is bleeding from gums, nose, or wounds that lasts more than 15 minutes or if blood appears in your urine, stool, or vomit.
• Do not stop taking the medication suddenly without talking to your doctor.

✔️ Indication of Intravas 40mg Injection

Enoxaparin is indicated for:

• Treatment of deep vein thrombosis, with or without pulmonary embolism.
• Treatment of unstable angina and non-Q-wave myocardial infarction, administered concurrently with aspirin.
• Prevention of thrombus formation in the extra-corporal circulation during hemodialysis.
• Prophylaxis of venous thromboembolic disease (prevention of blood clot formation in the veins), in particular those which may be associated with orthopedic or general surgery.
• Prophylaxis of venous thromboembolic disease in medical patients bedridden due to acute illness, including cardiac insufficiency, respiratory failure, severe infections, and rheumatic diseases.

✔️ Pharmacology

Enoxaparin Sodium is a low molecular weight heparin with high anti-Xa activity and low anti-IIa or antithrombin activity. It does not increase bleeding time at the dosages used for various indications. At prophylactic doses, it does not significantly alter activated Partial Thromboplastin Time (aPTT). It does not affect platelet aggregation or the binding of fibrinogen to platelets. Enoxaparin Sodium is primarily metabolized in the liver.

✔️ Dosage & Administration of Intravas 40mg Injection

For the treatment of deep vein thrombosis, with or without pulmonary embolism, the recommended dose of Enoxaparin Sodium is either 100 anti-Xa lU/kg twice daily for 10 days or 150 anti-Xa lU/kg once daily for 10 days. Oral anticoagulant therapy should be initiated as appropriate, and Enoxaparin Sodium treatment should be continued until a therapeutic anticoagulant effect has been achieved.

For the treatment of unstable angina and non-Q-wave myocardial infarction, Enoxaparin Sodium is administered subcutaneously at 100 anti-Xa lU/kg twice daily for 2-8 days, along with oral aspirin (100 to 325 mg once daily). Treatment with Enoxaparin Sodium should be prescribed for a minimum of 2 days and continued until clinical stabilization.

For the prevention of thrombus formation in extracorporeal circulation during hemodialysis, the recommended dose is 100 anti-Xa lU/kg. For patients at a high risk of hemorrhage, the dose should be reduced to 50 anti-Xa lU/kg for double vascular access or 75 anti-Xa lU/kg for single vascular access. Enoxaparin Sodium should be introduced into the arterial line of the circuit at the beginning of the dialysis session.

For prophylaxis of venous thromboembolic disease in surgical patients, the dose varies depending on the type of surgery. For general surgery with a moderate risk of thromboembolism, the recommended dose is 2000 anti-Xa IU (0.2 ml) or 4000 anti-Xa IU (0.4 ml) once daily for 7 to 10 days. For orthopedic surgery with a high risk of thromboembolism, the recommended dose is 4000 anti-Xa IU (0.4 ml) once daily for 7 to 10 days. The first injection should be given before the surgical procedure as per the time specified.

For prophylaxis of venous thromboembolic disease in medical patients, the recommended dose is 4000 anti-Xa IU (0.4 ml) once daily for 6-14 days.

It's important to note that  Intravas 40mg Injection should be administered by a doctor or a nurse either intravenously or subcutaneously. In some cases, self-administration may be advised by the physician, and in such cases, the patient should carefully follow the instructions given by the doctor. The appropriate dose and duration of therapy will be determined by your doctor based on your age, body weight, and medical condition.

✔️ Interaction

 Intravas 40mg Injection 0.4 ml may interact with several drugs, such as painkillers, blood thinners, drugs used to treat asthma and medications that increase potassium levels in the blood. It is also advised to avoid consuming alcoholic beverages while using this medication.

In addition,  Intravas 40mg Injection 0.4 ml may have interactions with various disease conditions, including hemophilia, liver disease, peptic ulcer disease, retinopathy, subacute bacterial endocarditis, active bleeding, hypertension, renal dysfunction, thrombocytopenia, prematurity, and kidney disease. It is important to inform your doctor about any existing medical conditions before using this medication.

✔️ Contraindications

Patients who have previously been allergic to Enoxaparin Sodium, heparin, or other low molecular weight heparins. Active major bleeding and conditions that increase the risk of uncontrolled hemorrhage, such as recent hemorrhagic stroke.

✔️ Pregnancy & Lactation

Enoxaparin Sodium is classified as Pregnancy Category B, indicating that there is no evidence of it crossing the placental barrier in humans. However, since there are no sufficient and well-controlled studies in pregnant women, it should be used during pregnancy only if clearly needed. Pregnant women with mechanical prosthetic heart valves may be at a higher risk for thromboembolism.

It is not known whether Enoxaparin is excreted in human milk. Considering the potential for serious adverse reactions in nursing infants due to the excretion of many drugs in human milk, a decision should be made whether to discontinue nursing or suspend Enoxaparin, taking into account the importance of Enoxaparin to the mother and the known benefits of nursing.

✔️ Precautions & Warnings

Patients should inform their doctor if they are on active treatment with  Intravas 40mg Injection 0.4 ml before any surgery is scheduled. If they have any known allergies to  Intravas 40mg Injection or any other medicines, they should inform their doctor. For pregnant or breastfeeding individuals, it is important to inform the doctor before using  Intravas 40mg Injection 0.4 ml.

Before using  Intravas 40mg Injection 0.4 ml, patients should disclose any pre-existing medical conditions, such as stomach ulcer, recent brain/eye/spine surgery, recent bleeding stroke, diabetes, high blood pressure, recent stroke, or kidney/liver disorders. Additionally, it is important to inform the doctor if they are underweight or overweight, or have high levels of potassium in their blood.

✔️ Storage Conditions

• Keep  Intravas 40mg Injection) out of reach of children
• Store  Intravas 40mg Injection at room temperature